Chronic obstructive pulmonary disease (COPD), which includes emphysema and chronic bronchitis, is a long-term lung disease that narrows the airways and damages the air sacs, making it harder to move air out of the lungs. Smoking is the most common cause, but COPD can also come from secondhand smoke, workplace dusts and fumes, and a genetic condition called alpha-1 antitrypsin deficiency.